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Dibasic sodium phosphate dihydrate USP/Ph.Eur/BP PARENTEX – high reproducibility pH buffer excipient for pH-sensitive formulations

Dibasic sodium phosphate dihydrate USP/Ph.Eur/BP PARENTEX ensures precise, reproducible pH control for injectables, peptides, and effervescent systems. Ideal for high-end pharmaceutical formulations. 

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    1. General Introduction to Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX

    Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX is a pharmaceutical-grade pH buffering excipient engineered for pH-sensitive formulations that require high stability. It is widely used in injectable drugs, peptide formulations, effervescent tablets and advanced dosage forms.

    This product is typically used when:

    • Formulations exhibit pH drift between batches
    • Scale-up leads to variability in results
    • APIs are highly dependent on pH conditions

    2. Composition of Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX

    • Chemical formula: Na₂HPO₄·2H₂O
    • Function: pH buffering excipient
    • Standards: USP / Ph.Eur / BP

    The dihydrate form helps maintain equilibrium stability in solution, reducing pH fluctuations during manufacturing.

    3. Key advantages of Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX

    • High batch-to-batch pH reproducibility
    • Predictable buffering behavior during scale-up
    • Reduced risk of API degradation
    • Enhanced stability for pH-sensitive formulations
    • Strong support for regulatory documentation and submissions

    4. Applications of Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX

    Pharmaceutical Applications
    • Injectable formulations (buffer systems): Maintain stable pH in parenteral solutions, minimizing precipitation and API degradation; commonly used in injectable antibiotics, anesthetics, and peptide drugs
    • Peptide / biologics: Stabilize microenvironmental pH to preserve structural integrity and biological activity, reducing potency loss during storage
    • Premium effervescent tablets: Precisely control acid–base reaction rates, ensuring consistent dissolution performance across batches
    • Modified-release (MR/CR) tablets: Stabilize the dissolution pH environment, supporting consistent drug release profiles
    Premium Cosmetic Applications
    • Vitamin C / peptide serums: Stabilize pH to reduce oxidation and maintain active efficacy throughout the product lifecycle
    • pH-sensitive skincare products: Prevent discoloration and reduce degradation of sensitive actives such as AHA, BHA, and vitamins
    • High-end cosmetics: Extend shelf life and ensure batch-to-batch consistency
    Dietary Supplement Applications
    • Functional beverages: Maintain stable pH to preserve taste and product stability throughout shelf life
    • Export products: Ensure batch consistency to meet international market requirements
    • pH-sensitive supplements: Stabilize the formulation environment to preserve potency of vitamins, minerals, and bioactive compounds

    5. Commercial Products Using Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX

    6. Product contact Information

    For more information regarding the supply of Dibasic Sodium Phosphate Dihydrate USP/Ph.Eur/BP PARENTEX, please contact us:

    • Hotline: +84 (0) 834 560 500
    • Email: director@biorichgroup.com
    • Website: www.biorichgroup.com
    • Sample / COA Request: Please contact us via email to receive the latest Sample and Certificate of Analysis (COA).
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