Methacrylic acid & Ethylacrylate copolymer (1:1) – Enteric film coating excipient for optimal active ingredient protection and targeted release

1. General Introduction to Methacrylic acid & Ethylacrylate copolymer (1:1)

Methacrylic acid & Ethylacrylate copolymer (1:1) is a gastric acid-resistant polymer widely used as an advanced enteric film coating excipient. With a 1:1 copolymer ratio, the resulting film does not dissolve in the harsh acidic environment of the stomach but only dissolves and releases the active ingredient in environments with pH > 5.5 (such as in the duodenum).

This is the perfect solution to protect active pharmaceutical ingredients sensitive to gastric acid, while preventing the risk of gastric mucosal irritation and ensuring maximum absorption in the small intestine, providing high stability for solid dosage forms.

2. Raw Material Information of Methacrylic acid & Ethylacrylate copolymer (1:1)

• Raw Material Name: Methacrylic acid & Ethylacrylate copolymer (1:1)
• Origin: India
• Material Group: Pharmaceutical Excipients / Coating agent.
• Function: Enteric coating, controlled release, protection of active ingredients from gastric acid.
• Chemical Composition: Copolymer of methacrylic acid and ethyl acrylate at a 1:1 ratio.
• Physical Form: Fine white powder or aqueous dispersion (depending on the product code), with a mild characteristic odor.
• Solubility: Insoluble in pure water and gastric acid, soluble in dilute alkaline environments (pH > 5.5) and organic solvents such as ethanol, isopropanol.
• Quality Standards: Complies with current international pharmacopoeias (USP/Ph.Eur/BP).

The raw material is strictly controlled for:

• Copolymer Ratio: Accurately controlled to ensure the coating film dissolves only at the exact target pH level.
• Impurity Limits: Ensures high chemical stability during storage and excellent compatibility with a wide range of active ingredients.

3. Advantages of the Raw Material

• Superior Active Ingredient Protection: The copolymer film completely prevents the degradation of sensitive active ingredients (such as enzymes, peptides, antibiotics, probiotics) by gastric acid.
• Gastric Mucosa Protection: Avoids side effects that cause gastric ulcers or irritation from certain specific drugs (such as NSAIDs).
• Targeted Release Control: Ensures precise and rapid release of active ingredients in the duodenum or proximal small intestine, thereby optimizing product bioavailability.
• High Flexibility - Wide Application: The coating film has good toughness, excellent adhesion, and is easy to apply in formulations for coating tablets, hard capsules, and pellets.

4. Applications of Methacrylic acid & Ethylacrylate copolymer (1:1)

In Pharmaceuticals (Core Application)

• Manufacturing of Tablets and Capsules: The largest application, used as a film coating excipient to protect proton pump inhibitors (PPIs), analgesics, anti-inflammatories, and active ingredients needing intestinal absorption.
• Pellet Coating and MUPS: Used in pellet manufacturing technology to control the uniform and sustained release of active pharmaceutical ingredients.

In Health Supplements

• Protection of Probiotics and Enzymes: Applied to oral capsules containing probiotics or digestive enzymes, helping them safely survive the gastric acid barrier to take effect in the intestine.

5. Commercial Products Using Methacrylic acid & Ethylacrylate copolymer (1:1)

6. Product Contact Information

For more information about the supply chain, technical specifications of Methacrylic acid & Ethylacrylate copolymer (1:1) or to place an order, please contact us:

• Consultation Hotline: +84 (0) 834 560 500
• Email: director@biorichgroup.com
• Website:www.biorichgroup.com
• Request for Sample/COA: Please contact us via email to request a sample and the latest Certificate of Analysis (COA) of the raw material.