Polyvinyl Alcohol (PVA)

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1. General Introduction to Polyvinyl Alcohol (PVA)

Polyvinyl Alcohol (PVA) is a widely used pharmaceutical excipient with diverse applications in pharmaceutical formulation and manufacturing. Its most common application is as a film-forming agent for moisture-protective film-coated tablets. PVA provides an effective moisture barrier, reducing water vapor uptake, protecting moisture-sensitive active pharmaceutical ingredients (APIs), and maintaining the stability of the finished dosage form throughout its shelf life.

Beyond moisture-protective film coating, PVA is also extensively used in liquid formulations, ophthalmic preparations, and topical dosage forms as a gelling agent, suspending agent, emulsifying agent, and solubilization enhancer. In addition, it serves as a release-modifying polymer in sustained-release formulations, enabling prolonged drug release and improved therapeutic performance.

Polyvinyl Alcohol is produced using advanced synthesis and purification technologies, offering high purity, stringent impurity control, excellent batch-to-batch consistency, and full compliance with the most rigorous international pharmacopeial standards.

2. Polyvinyl Alcohol (PVA) Raw Material Information

Material Name: Polyvinyl Alcohol (PVA)
Country of Origin: China
Material Category:Pharmaceutical Excipient
Functions:Film-forming agent for film-coated tablets, tablet binder, thickening agent, suspending agent for liquid formulations, and release-modifying polymer for sustained-release dosage forms.
Chemical Nature: Synthetic polymer with the general chemical formula [–CH₂–CH(OH)–]ₙ.
Physical Appearance: White to off-white crystalline powder or fine granules, odorless or with a faint characteristic odor.
Solubility: Freely soluble in water. Depending on the degree of hydrolysis, it may dissolve at room temperature or require heating for complete dissolution. Practically insoluble in organic solvents.
Quality Standards: Complies with the specifications of the United States Pharmacopeia (USP), European Pharmacopoeia (Ph. Eur.), and/or Chinese Pharmacopoeia (ChP).

The raw material is strictly controlled for:

Residual Solvent Limits: Strict control of residual solvents during the synthesis process, ensuring absolute safety for oral and mucosal administration.
Degree of Hydrolysis and Molecular Weight: Ensures precise technical specifications to maintain stable viscosity and the ability to form tough, glossy films.
Heavy Metal and Microbial Indices: Meets stringent microbiological standards for oral preparations and eye drops.

3. Key advantages of Polyvinyl Alcohol

Non-ionic polymer, thus it does not interact with active pharmaceutical ingredients.
Forms a protective film coating that serves as a moisture and gas barrier, providing an elegant appearance and excellent adhesion to tablet cores, thereby minimizing the risk of film peeling or logo bridging.
Low viscosity allows for a high solid content in the coating dispersion (up to 20%), improving coating efficiency and reducing processing time.
Freely soluble in water.
Studies have demonstrated that PVA exhibits lower water vapor permeability compared to HPMC, providing superior moisture protection for hygroscopic or moisture-sensitive drugs.
Moisture-protective coatings using PVA do not affect drug release profiles.
Flexible in formulation development and offers easier control over raw material sourcing compared to ready-to-use coating systems.
Product complies with USP/EP/BP
The manufacturer has EXCIPACT GMP Certificate for Pharma application

4. Applications of Polyvinyl Alcohol (PVA)

In Pharmaceuticals

Film-forming agent providing moisture protection for coated tablets.
Binding agent for wet granulation processes.
Gelling and suspending agent for liquid preparations, ophthalmic solutions, and topical formulations.
Emulsifying agent that enhances the solubility of poorly soluble active ingredients in pharmaceutical emulsions.
Sustained-release agent that prolongs drug release in extended-release tablet formulations.

In Cosmetics

Widely used in peel-off masks due to its adhesive film-forming and easy-peeling capabilities

5. Commercial Products Using Polyvinyl Alcohol

6. Product Contact Information

For more information on the supply chain and technical specifications of Polyvinyl Alcohol (PVA), or to place an order, please contact us:

Consultation Hotline: +84 (0) 834 560 500
Email: director@biorichgroup.com
Website:www.biorichgroup.com
Request Sample/COA: Please contact us via email to request testing samples and the latest Certificate of Analysis (COA) for the raw material from the manufacturer

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Polyvinyl Alcohol (PVA) – Moisture barrier film-coated polymer

1. General Introduction to Polyvinyl Alcohol (PVA)

2. Polyvinyl Alcohol (PVA) Raw Material Information

3. Key advantages of Polyvinyl Alcohol

4. Applications of Polyvinyl Alcohol (PVA)

5. Commercial Products Using Polyvinyl Alcohol

6. Product Contact Information

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