Povidone K17 – High performance binder and solubility enhancer

1. General introduction to Povidone K17

Povidone K17is a non-ionic polymer belonging to the polyvinylpyrrolidone (PVP) family, with a K-value of approximately 17, corresponding to a low molecular weight. This provides key functional properties such as low viscosity, rapid solubility, and high mobility in solvent systems.

Thanks to its polar lactam structure, Povidone K17 is capable of forming hydrogen bonds with active pharmaceutical ingredients (APIs), enhancing molecular-level dispersion and supporting the maintenance of the amorphous state of drug substances. This mechanism plays a critical role in improving apparent solubility and inhibiting recrystallization, particularly for poorly water-soluble compounds.

Povidone K17 demonstrates clear advantages in formulations requiring high clarity, low viscosity, and rapid diffusion, while also reducing the risk of accumulation in the body. As a result, it is an optimal choice for formulations demanding high purity, excellent tolerability, and enhanced bioavailability, especially in sensitive dosage forms such as ophthalmic, parenteral, and advanced liquid systems.

2. Active composition of Povidone K17

Povidone K17 does not contain any active pharmaceutical ingredient (API) and functions as a specialized pharmaceutical excipient.

Its primary component is polyvinylpyrrolidone (PVP) – a water-soluble polymer that is also soluble in various organic solvents, offering excellent biocompatibility and stability across a wide range of formulation conditions.

With its unique chemical structure, Povidone K17 serves not only as a binder, but also as a solubility enhancer and stabilizing agent, contributing to improved overall formulation performance.

3. Key Advantages of Povidone K17

• Low viscosity, ideal for solution systems requiring high clarity and stability
• Rapid solubility, reducing processing time and improving manufacturing efficiency
• Enhances solubility and bioavailability of poorly soluble APIs
• Inhibits recrystallization, improving long-term formulation stability
• Improves biological tolerability, especially in ophthalmic and parenteral products
• Reduces risk of accumulation due to low molecular weight
• Excellent compatibility with a wide range of APIs and excipients
• Suitable for multiple manufacturing technologies such as spray drying, solution processing, and lyophilization

4. Applications of Povidone K17

In Pharmaceuticals:

• Binding excipient for tablets and capsules
• Enhances solubility of poorly soluble active ingredients (BCS II & IV)
• Carrier excipient in solid dispersion systems
• Stabilizes solutions, suspensions, ophthalmic formulations, and injectables

In Cosmetics:

• Film-forming polymer in gels and hair sprays
• Stabilizes emulsions and serums
• Provides smooth, non-greasy texture
• Improves adhesion and prolongs product efficacy

In Food & Dietary Supplements:

• Binding excipient for supplement tablets
• Stabilizes beverages and functional foods
• Delivers nutritional actives efficiently
• Enhances uniformity and overall product quality

Povidone K17 empowers businesses to develop high-performance, multi-industry products with significant added value.

5. Sample Povidone K17 products 

6. Product contact information

For more information about sourcing Povidone K17, please contact us:

• Nutra Hotline: +84 (0) 834 560 500
• Email: biopharma@biorichpharma.com
• Website: www.biorichpharma.com
• Sample / COA Request: Please contact us via email to request samples and the latest Certificate of Analysis (COA).