Sodium Starch Glycolate – A widely used superdisintegrant with rapid water uptake and fast swelling capacity

1. General Introduction to Sodium Starch Glycolate

Sodium Starch Glycolate (SSG) is one of the most widely used superdisintegrants in pharmaceutical formulations. It is derived from natural starch—typically potato, corn, or rice starch—through carboxymethylation and cross-linking, resulting in a cross-linked structure that rapidly absorbs water and swells without dissolving.

Owing to its excellent water uptake and rapid swelling properties, SSG enables tablets and capsules to disintegrate quickly upon contact with gastrointestinal fluids, thereby promoting faster drug dissolution and enhancing the absorption of the API.

Manufactured using advanced production technology, this excipient delivers outstanding quality with stringent control of microbial limits and impurities. It ensures exceptional batch-to-batch consistency while fully complying with the most rigorous requirements of major global pharmacopeias.

2. Material Information of Sodium Starch Glycolate

• Material Name: Sodium Starch Glycolate
• Origin: India
• Material Group: Pharmaceutical Excipients.
• Function: Helps tablets and capsules disintegrate quickly, enhancing solubility and absorption of API.
• Chemical nature:The sodium salt of cross-linked carboxymethyl starch.
• Material Form: White or off-white, free-flowing powder, odorless or with a slight odor.
• Solubility: Practically insoluble in water but swells immensely in water; insoluble in most organic solvents.
• Quality Standards: Meets US Pharmacopeia (USP), European Pharmacopoeia (EP), or British Pharmacopoeia (BP) standards.

The material is specially and strictly controlled for:

• Swelling capacity: Ensures optimal swelling in aqueous environments (many times its original volume) to break down the tablet structure quickly.
• Impurity and microbial limits: Strictly controls heavy metal content and meets stringent microbial standards for oral preparations.

3. Advantages of Sodium Starch Glycolate

• Excellent Disintegration Performance:Rapid water uptake and extensive swelling enable fast tablet disintegration, even at low use levels (typically 2–8%).
• High Compatibility:Suitable for various tablet manufacturing processes, including direct compression, wet granulation, and dry granulation, with excellent compatibility with most active pharmaceutical ingredients (APIs).
• Outstanding Stability:Maintains excellent disintegration performance even under high compression forces and throughout the product's shelf life, while having minimal impact on tablet hardness.
• Cost-Effective with a Reliable Supply: Manufactured in India, the product offers a highly competitive cost advantage and a stable supply chain, providing an efficient solution for pharmaceutical manufacturers to optimize production costs without compromising quality.

4. Applications of Sodium Starch Glycolate

In Pharmaceuticals

• Tablets and capsules: Acts as a superdisintegrant (added both intra-granularly and extra-granularly) for solid oral dosage forms, facilitating the rapid release of API.

In Health Supplements

• Nutritional supplement tablets: Applied in vitamin, mineral, or herbal extract tablets to ensure the product disintegrates easily in the stomach, maximizing absorption.

5. Commercial Products Using Sodium Starch Glycolate

6. Product Contact Information

For more information on the supply chain, technical specifications of Sodium Starch Glycolate, or to place an order, please contact us:

• Consulting Hotline: +84 (0) 834 560 500
• Email:director@biorichgroup.com 
• Website:www.biorichgroup.com
• Sample/COA Request: Please contact us via email to request a test sample and the latest Certificate of Analysis (COA) of the raw material from the manufacturer.