1. General introduction to Disodium Edetate 

Disodium Edetate is a chelating excipient capable of binding metal ions and is widely used in pharmaceutical, cosmetic and food applications to enhance formulation stability and minimize oxidation processes.

Through its strong chelation capacity toward divalent and trivalent metal ions, Disodium Edetate helps protect sensitive active ingredients from metal-catalyzed degradation, thereby extending shelf life and maintaining finished product quality.

In advanced pharmaceutical and cosmetic formulations, Disodium Edetate is recognized as an essential excipient for optimizing chemical stability, improving preservative performance, and enhancing compatibility within modern formulation systems.

2. Active ingredient profile of Disodium Edetate excipient

• Active ingredient name: Disodium Edetate
• Chemical name: Disodium EDTA
• Functional class: Chelating agent
• Molecular formula: C10H14N2Na2O8·2H2O
• Molecular weight: 372.24 g/mol
• Appearance: White crystalline powder
• Solubility: Freely soluble in water
• Solution pH: Approximately 4.0 – 5.5
• Quality standards: USP/NF, EP, BP, JP

Disodium Edetate demonstrates strong chelation capability with metal ions such as calcium, magnesium, iron, and copper, helping reduce oxidative reactions and improve stability in sensitive formulation systems.

3. Key advantages of Disodium Edetate 

• Strong chelation capability: Forms stable complexes with metal ions such as Fe³⁺, Cu²⁺, Ca²⁺, and Mg²⁺, helping minimize metal-catalyzed oxidation reactions.
• Enhanced formulation stability: Helps protect oxidation-sensitive active ingredients from discoloration, potency loss, and degradation.
• Improved preservative system performance: Supports the effectiveness of selected preservative systems in pharmaceutical and cosmetic formulations.
• Broad compatibility with formulation systems: Suitable for solutions, emulsions, gels, and formulations containing oxidation-sensitive ingredients.
• Excellent water solubility: Easily dispersed in aqueous systems and suitable for industrial-scale manufacturing and scale-up processes.
• High chemical stability: Maintains stable chelation performance under standard manufacturing and storage conditions.
• Compliance with international pharmacopeial standards: Complies with USP/NF, EP, and BP standards, making it suitable for high-quality pharmaceutical and cosmetic formulations.

4. Applications of Disodium Edetate

In pharmaceutical formulations

• Injectable solutions: Helps control metal ions and improve stability of oxidation-sensitive active ingredients.
• Ophthalmic solutions: Supports formulation stability and enhances preservative system performance in sterile products.
• Oral liquid formulations: Helps minimize discoloration and maintain finished product stability.
• Topical creams and gels: Stabilizes emulsion systems and protects active ingredients from metal-catalyzed oxidation.
• Vitamin formulations: Helps protect oxidation-sensitive vitamins from degradation caused by metal ions.

In cosmetic formulations

• Facial serums: Helps stabilize active ingredients and maintain long-term formulation quality.
• Skin creams: Supports preservative performance and emulsion stability.
• Facial cleansers: Improves formulation stability and helps control the effects of metal ions in water systems.
• Anti-aging products: Helps minimize oxidation and protect sensitive active ingredients.
• Hair care products: Improves formulation stability and enhances the performance of functional ingredients.

In food applications

• Functional beverages: Helps stabilize color and minimize oxidation during storage.
• Processed food products: Controls metal ions to maintain sensory quality and product stability.

5. Commercial products using Disodium Edetate

6. Product contact information

For further information regarding Disodium Edetate supply capability, technical specifications, or commercial inquiries, please contact us:

• Hotline: +84 (0) 834 560 500
•  Email: director@biorichgroup.com
•  Website: Biorich Group
• Sample & COA Request: Please contact us via email to request product samples and the latest Certificate of Analysis (COA).